Polynucleotides (PNs) are naturally occurring molecules derived from purified DNA fragments, typically sourced from salmon or trout. When injected into the skin, they trigger your body's own biological repair mechanisms — stimulating collagen production, enhancing elasticity, and deeply hydrating the skin from within.

Unlike dermal fillers which add volume, polynucleotides work by regenerating and repairing your own skin tissue. They represent a 'less is more' approach — improving skin quality, texture, and hydration without relying on synthetic materials to fill or plump.

Polynucleotides are effective for the face, neck, hands, and particularly the delicate under-eye area. The under-eye area is especially well-suited as it is too delicate for most fillers, but responds exceptionally well to the regenerative properties of PNs.

A treatment course typically consists of 1–3 sessions, spaced 3–4 weeks apart. The exact number depends on your skin condition and goals, which your doctor will assess during your consultation.

Minor swelling resolves quickly after treatment. Noticeable improvements appear within a week, with peak results at around 28 days after your second session. The collagen stimulation continues to improve your skin for weeks after treatment.

Results typically last up to 9 months, though this varies by patient and the area treated. Many patients choose to have maintenance treatments once or twice a year to sustain their results.

Treatment uses tiny needles combined with numbing creams and our TargetCool freezing technology for a practically painless experience. Most patients describe only mild discomfort. Each area takes approximately 20 minutes to treat.

Downtime is minimal. You may experience minor swelling, redness, or small injection marks which typically resolve within 24–48 hours. Avoid strenuous exercise, alcohol, and excessive heat for 48 hours. No makeup for 24 hours after treatment.

Yes. Polynucleotides have been used in medicine for decades in wound healing and tissue regeneration. The purified DNA fragments are biocompatible and naturally metabolised by the body. They have an excellent safety profile with minimal risk of allergic reaction.

Polynucleotide treatments at Amara Clinic start from €400 per area. During your consultation, we'll create a personalised treatment plan with transparent pricing based on your specific goals and the areas you'd like to treat.

Yes. Polynucleotides complement other treatments such as Profhilo, dermal fillers, and anti-wrinkle injections. Your doctor will advise on the best combination and timing during your consultation.

Yes, a consultation with one of our experienced injectors is required. This includes a thorough skin examination to determine if polynucleotides are right for you and to create your personalised treatment plan.